The Clinical Pharmacology Unit was established in 1985. We were the first example in the University of NHS funding for academic developments. In 1998 we moved into our purpose-built clinical and basic science laboratories in the Addenbrooke's Centre for Clinical Investigation, funded by the BHF and an MRC Technology Foresite grant (joint with Cardiovascular Medicine and Neurosurgery). Although our work is mainly academic, we have been strong protagonists of translational research long before this became a common buzzword. Many of our research outputs have been translated rapidly into improving practices, mainly in hypertension, where both diagnosis and treatment has been transformed by our AB/CD rule, and use of plasma renin as a routine test in most patients. Members of the Clinical Pharmacology Unit hold senior positions in the British Hypertension Society and British Pharmacological Society. We give equal weight to the clinical and non-clinical members of the Unit, encouraging the clinicians to learn basic science skills, and the scientists to take part in patient-orientated research.
Most of the research, described by individual PIs, is cardiovascular, including hypertension, arterial stiffness, genetics of sodium handling, ischemia/reperfusion, and action on the circulation of G-protein coupled receptors.
As well as research and clinical work, the Unit undertakes teaching of undergraduates and training of junior doctors in Clinical Pharmacology and Therapeutics. We have taken the lead in creating programmes of dual training in CPT and an organ-based specialty. Our trainees have progressed to Consultant posts in Cardiology, Respiratory Medicine, Nephrology and Endocrinology/Metabolic Medicine. In response to the MTAS debacle, and politicisation of training under MMC, we expect to convert most of our SpR posts to Clinical Lectureships.
Research in the Clinical Pharmacology Unit is funded by: