Dr Ian Wilkinson
Dr Ian Wilkinson
Position(s):
Reader in Clinical Pharmacology, University of Cambridge;
Honorary Consultant Physician, Cambridge University Hospitals NHS Foundation Trust;
Fellow of Trinity Hall College, University of Cambridge.
Email: ibw20@cam.ac.uk
Tel: 01223 336898
Also Director of the new Cambridge University Health Partners' Clinical Trials Unit and WE Parkes British Heart Foundation Senior Clinical Fellow. I am also secretary of the ARTERY Society, and Treasurer of the British Hypertension Society.
Research Description
My research interest centres on the physiology and pharmacology of the cardiovascular system, and particularly hypertension, the large arteries and endothelial function. Current research projects include investigating the effect of ageing on the cardiovascular system, the link between inflammation and arterial function, and the effect of novel nitric oxide donors on pre-eclampsia. I am also involved in a number of large collaborative studies including CLEAREST Study, the Caerphilly Heart Study, ENIGMA Study and Whitehall II.
Funding
Group Members
| cmm41@cam.ac.uk | |
| km319@cam.ac.uk |
| lat24@cam.ac.uk | |
| jcs76@cam.ac.uk |
| km474@cam.ac.uk |
| jw574@cam.ac.uk |
| ld365@cam.ac.uk |
|
me204@cam.ac.uk |
Recent Publications
Cheriyan J, Webb AJ, Sarov-Blat L, Elkhawad M, Wallace SM, Mäki-Petäjä KM, Collier DJ, Morgan J, Fang Z, Willette RN, Lepore JJ, Cockcroft JR, Sprecher DL, & Wilkinson IB.
Inhibition of p38 Mitogen-Activated Protein Kinase Improves Nitric Oxide-Mediated Vasodilatation and Reduces Inflammation in Hypercholesterolemia. Circulation 123;515-523:2011.McEniery CM, Spratt M, Munnery M, Yarnell J, Lowe GD, Rumley A, Gallacher J, Ben-Shlomo Y, Cockcroft JR, & Wilkinson IB.
An Analysis of Prospective Risk Factors for Aortic Stiffness in Men. 20-Year Follow-Up From the Caerphilly Prospective Study. Hypertension 56;36-43:2010.McEniery CM, McDonnell BJ, So A, Aitken S, Bolton CE, Munnery M, Hickson SS, Yasmin, Maki-Petaja KM, Cockcroft JR, Dixon AK, & Wilkinson IB.
Aortic Calcification Is Associated With Aortic Stiffness and Isolated Systolic Hypertension in Healthy Individuals. Hypertension 53;524-531:2009.-
Kinra S, Rameshwar Sarma KV, Ghafoorunissa, Mendu VV, Ravikumar R, Mohan V, Wilkinson IB, Cockcroft JR, Davey SG, & Ben-Shlomo Y.
Effect of integration of supplemental nutrition with public health programmes in pregnancy and early childhood on cardiovascular risk in rural Indian adolescents: long term follow-up of Hyderabad nutrition trial. BMJ 337;445-452:2008. -
Maki-Petaja KM, Booth AD, Hall FC, Wallace SM, Brown J, McEniery CM, & Wilkinson IB.
Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis. J Am Coll Cardiol 50;852-858:2007. -
McEniery CM, Wallace YS, Maki-Petaja K, McDonnell B. Sharman JE, Retallick C, Franklin SS., Brown MJ, Lloyd RC, Cockcroft JR, & Wilkinson IB.
Increased Stroke Volume and Aortic Stiffness Contribute to Isolated Systolic Hypertension in Young Adults. Hypertension 46;221-226:2005 -
Schmitt M, Avolio A, Qasem A, McEniery CM, Butlin M, Wilkinson IB, & Cockcroft JR.
Basal NO Locally Modulates Human Iliac Artery Function In Vivo. Hypertension 46;227-241:2005. -
McEniery CM, Yasmin, Hall IR, Qasem A, Wilkinson IB, & Cockcroft JR (2005).
Normal Vascular Ageing: Differential Effects on Wave Reflection and Aortic Pulse Wave Velocity: The Anglo-Cardiff Collaborative Trial (ACCT 1). J Am Coll Cardiol 46, 1753-1760. -
Mackenzie IS, Maki-Petaja KM, McEniery CM, Bao YP, Wallace SM, Cheriyan J, Monteith S, Brown MJ, & Wilkinson IB.
Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans. Arterioscler Thromb Vasc Biol 25;1891-1895:2005. -
Booth AD, Jayne DRW, Kharbanda RK, McEniery CM, Mackenzie IS, Brown J, & Wilkinson IB.
Infliximab improves endothelial dysfunction in systemic vasculitis: a model of vascular inflammation. Circulation, 109;1718-1723:2004. -
Booth AD, Wallace S, McEniery CM., Yasmin, Brown, J, Jayne DRW, & Wilkinson IB.
Inflammation and arterial stiffness in systemic vasculitis: a model of vascular inflammation. Arthritis and Rheumatism, 50;581-518:2004. - Yasmin, McEniery CM, Wallace S, Mackenzie IS, Cockcroft J & Wilkinson I B.
C-Reactive Protein is Associated with Arterial Stiffness in Apparently Healthy Individuals. Arteriosclerosis Thrombosis and Vascular Biology 24:969-974.25:372-378:2004. -
Maki-Petaja KM, Hall FC, Booth AD, Wallace SM, Yasmin, Bearcroft PW, Harish S, Furlong A, McEniery CM, Brown J, & Wilkinson IB.
Rheumatoid arthritis is associated with increased aortic pulse-wave velocity, which is reduced by anti-tumor necrosis factor-alpha therapy. Circulation 114;1185-1192:2006. -
Yasmin, McEniery CM, O'shaughnessy KM, Harnett P, Arshad A, Wallace S, Maki-Petaja K, McDonnell B, Ashby MJ, Brown J, Cockcroft JR, & Wilkinson IB.
Variation in the Human Matrix Metalloproteinase-9 Gene Is Associated With Arterial Stiffness in Healthy Individuals. Arterioscler Thromb Vasc Biol 26;1799-1805:2006. -
McEniery CM, Qasem, A, Schmitt M, Avolio AP, Cockcroft JR. & Wilkinson, I. B.
Endothelin-1 regulates arterial pulse wave velocity in vivo. Journal of the American College of Cardiology, 42;1975-1981:2003. -
Wilkinson IB, Hall IR, MacCallum H, Mackenzie IS, McEniery CM, van der Arend BJ, Shu Y-E, MacKay LS, Webb DJ, & Cockcroft JR.
Pulse wave analysis: clinical evaluation of a non-invasive, widely applicable method for assessing endothelial function. Arteriosclerosis Thrombosis and Vascular Biology 22; 147-152:2002 -
Wilkinson IB, Prasad K, Hall IR, Thomas A, MacCallum H, Webb DJ, & Cockcroft JR.
Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia. Journal of the American College of Cardiology 39;1005-1011:2002. Wilkinson IB., Qasem A, McEniery CM., Webb DJ, Avolio AP, & Cockcroft JR.
Nitric oxide regulates local arterial distensibility in vivo. Circulation 105;213-217:2002.-
Wilkinson IB, MacCallum H, Flint L, Cockcroft J R, Newby DE, & Webb D J.
The influence of heart rate on augmentation index and central arterial pressure in humans. Journal of Physiology 525;263-270:2000.